• \*\*Healthy Controls:\*\*

∙ Age \> 18 years;

‣ Signed informed consent and willingness to participate in the project.

• \*\*Gastric Cancer:\*\*

⁃ Age ≥ 18 years;

⁃ Performance status (ECOG) score ≤ 1;

⁃ Histopathologically confirmed gastric adenocarcinoma;

⁃ No family history of hereditary cancer;

⁃ No prior anti-tumor treatment;

⁃ Availability of primary tumor tissue from surgery or biopsy that meets submission requirements;

⁃ Availability of peripheral blood samples that meet submission requirements;

⁃ Willingness and ability to sign the informed consent form to participate in the study.